Who is Using OpenStructure?

SWISS-MODEL - Expert System for Protein Structure Modelling

SWISS-MODEL is a widely used automated protein structure homology-modelling server for generating three-dimensional models of a protein. SWISS-MODEL automates the complex process of model building on an easy to use web based system, thereby making model information available also for non-specialists.

SWISS-MODEL is available at http://swissmodel.expasy.org

CAMEO - Continuous Automated Model EvaluatiOn

CAMEO is a community-wide project, running since January 2012, intended as complement to the bi-annual CASP experiment. CAMEO relies on the weekly PDB pre-release and performs a fully automated assessment of the performance of: protein structure prediction methods (category 3D), ligand binding prediction methods (category LB) and model quality estimation methods (category QE). CAMEO is continuously maintained and developed (beta.cameo3d.org) and actually counts 57 different methods registered that are developed by 18 different groups.

Project Website

QMEAN - Quality Assessment of Protein Structures

The QMEAN server provides access to two scoring functions successfully tested at the eighth round of the community-wide blind test experiment CASP. The user can choose between the composite scoring function QMEAN, which derives a quality estimate on the basis of the geometrical analysis of single models, and the clustering-based scoring function QMEANclust which calculates a global and local quality estimate based on a weighted all-against-all comparison of the models from the ensemble provided by the user.

Project Website

PMP - Protein Model Portal

The Protein Model Portal (PMP) gives access to the various models that can be leveraged from PSI targets and other experimental protein structures by comparative modeling methods. The current release of the portal allows searching 13.5 million precomputed model structures provided by different partner sites, and provides access to various interactive services for template selection, target-template alignment, model building, and quality assessment.

Project Website

IPLT - Images Processing Library and Toolkit

The Image Processing Library & Toolbox is an open-source project, released under the GPL. It is primarily aimed at the electron microscopy community, with particular emphasis on 2D electron crystallography. It consists of several modular class libraries written in C++, each exposing a majority of their interface to Python, upon which the processing logic is build.

Project Website

Project Funding

Swiss Institute of Bioinformatics

Biozentrum, University of Basel